In the world of film, scientific accuracy can sometimes take a backseat to dramatic effect. However, two researchers found themselves deeply involved in ensuring that science fiction remained grounded in reality. Ian Lipkin, an experimental pathologist at Columbia University, and James Dahlman, a biomedical engineer at Georgia Institute of Technology and Emory University, each had unique experiences advising on major films. Lipkin worked on "Contagion," a pandemic thriller, while Dahlman contributed to "Rampage," a sci-fi action movie featuring CRISPR technology. Both scientists emphasized the importance of blending realism with entertainment, showcasing how their expertise could enhance storytelling.

The Making of Contagion: A Pandemic Thriller

In the fall of 2009, screenwriter Scott Burns sought out Ian Lipkin's help to craft a movie about a global pandemic. Lipkin, known for identifying over 2,500 viruses and contributing to containment strategies during outbreaks, was approached by Burns after Larry Brilliant recommended him. Brilliant, an epidemiologist, had previously met Lipkin through Pandefense Advisory. The collaboration began with a shared vision: to create a film that would not only entertain but also educate audiences about realistic pandemic responses.

Burns and director Steven Soderbergh aimed to depict a plausible outbreak scenario, focusing on the chain of events from the first infected individual to the public health response. With funding from Participant Media, a production company dedicated to addressing societal issues, including healthcare, the team worked diligently to ensure scientific authenticity. Lipkin advised on selecting a paramyxovirus as the fictional pathogen and provided insights into laboratory techniques, even teaching actors how to perform scientific procedures accurately. Despite some compromises due to budget constraints, Lipkin’s involvement significantly enhanced the film's realism.

Rampage: Bringing CRISPR to Life

James Dahlman initially hesitated when asked to consult on a CRISPR-themed movie called "Rampage." Concerned about the potential for sensationalism, he eventually agreed after learning it was a legitimate production. The film centered around a biotech company developing a gene-editing pathogen that turned animals into monstrous creatures. Dahlman’s role included training actors in lab techniques, such as pipetting, and ensuring the set design reflected a real biosafety laboratory. His attention to detail extended to organizing the lab space and teaching actors appropriate behaviors, like wearing gloves when handling reagents.

While Dahlman recognized that full realism was unattainable in a fictional setting, he was pleased with the team's commitment to accuracy. He even made a cameo appearance in the film as an FBI agent. For Dahlman, the experience was both educational and rewarding, offering a glimpse into the intricate process of filmmaking and the opportunity to engage with actors about science.

Reflecting on his time as a consultant, Dahlman noted the value of bridging the gap between science and entertainment. “It was a dream come true,” he said, emphasizing the importance of making science accessible and engaging to a broader audience.

A Reflection on the Experience

For both Lipkin and Dahlman, their involvement in these films highlighted the power of combining scientific knowledge with creative storytelling. Lipkin’s work on "Contagion" not only educated viewers about pandemics but also prepared him for real-world challenges, such as developing safety protocols during the COVID-19 pandemic. Dahlman’s experience with "Rampage" underscored the importance of accurate representation in science fiction, even when the subject matter is fantastical. Both scientists agree that their roles as consultants were unique opportunities to influence public perception of science, demonstrating that entertainment can serve as a powerful tool for education and awareness.