On the UK version of Celebrity Big Brother, an unexpected friendship blossomed between Chris Hughes and JoJo Siwa. This connection captured the audience's attention as it unfolded on screen through intimate moments shared by the two. From giving each other makeovers to exchanging heartfelt handwritten notes, their interactions revealed a deep bond that transcended ordinary friendships. During this time, Siwa ended her relationship with Kath Ebbs at a post-show party, emphasizing the impact Hughes had on her emotional journey.

Hughes described their unique relationship as something profound and difficult to articulate during an appearance on the UK’s This Morning. He highlighted the beauty of having someone consistently present through highs and lows, referring to Siwa as a "soulmate friendship." Beyond their reality show experiences, Hughes is a multifaceted personality with diverse interests and achievements. Originally from England, he grew up in the picturesque Cotswolds but pursued various careers including music collaborations with fellow Love Island star Kem Cetinay and television presenting roles focusing on horse racing, reflecting his lifelong passion for equines.

Chris Hughes has also been actively involved in cancer advocacy following his brother's diagnosis. In 2019, he used social media platforms to raise awareness about testicular cancer after his sibling discovered a lump thanks to knowledge gained from one of Hughes' televised health checks. Their story was later documented in a BBC special titled Me, My Brother and Our Balls, showcasing resilience and education around men's health issues. Such endeavors underscore Hughes' commitment not only to personal growth but also to contributing positively towards societal awareness and change.